​Mechanism of Action

Naronapride is an orally bioavailable, small organic molecule. It was designed to be a potent and selective serotonin 5-HT4 receptor agonist. Stimulating 5-HT4 receptors in the gut wall promotes the release of acetylcholine, which works to increase motility of the GI tract. The high 5-HT4 receptor selectivity minimizes the potential for off-target pharmacological effects. Indeed, it has been shown in animals and in humans to be safe and devoid of adverse cardiovascular effects.